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Compound Summary

Compound Information

selegiline

Compound Name:	selegiline
Compound CID:	26757
Synonyms:	selegiline L-Deprenalin L-Deprenyl (-)-selegiline Emsam More...
Iupac Name:	(2R)-N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine
InChI:	InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/m1/s1
InChIKey:	MEZLKOACVSPNER-GFCCVEGCSA-N
Canonical Smiles:	CC(CC1=CC=CC=C1)N(C)CC#C
Isomeric Smiles:	C[C@H](CC1=CC=CC=C1)N(C)CC#C
Molecular Weight:	187.28
Molecular Formula:	C13H17N

Compound Structure

2D Structure:

3D Structure:

Computed Properties

selegiline

Molecular Weight:	187.28
Molecular Formula:	C13H17N
Hydrogen Bond Donor Count:	0
Hydrogen Bond Acceptor Count:	1
Rotatable Bond Count:	4
Heavy Atom Count:	14
Complexity:	195

Synonyms

selegiline

selegiline	selegiline
selegiline	L-Deprenalin
L-Deprenyl	(-)-selegiline
Emsam	14611-51-9
Eldepryl	Zelapar
Jumex	Selegilinum
Selegilina	UNII-2K1V7GP655
Selegilinum INN-Latin	Selegilina INN-Spanish
N-methyl-N-(2R)-1-phenylpropan-2-ylprop-2-yn-1-amine	CHEMBL972
CHEBI:9086	Carbex
2K1V7GP655	Otrasel
(2R)-N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine	(-)-Deprenil
selgene	Anipryl
(R)-N-Methyl-N-(1-phenylpropan-2-yl)prop-2-yn-1-amine	Zalapar
l-E 250	(R)-(-)-Selegiline
Selegene	Selegiline USAN:INN:BAN
(R)-(-)-N,alpha-Dimethyl-N-2-propinylphenethylamine	Emsam (TN)
(R)-(-)-N-Methyl-N-(1-phenyl-2-propyl)-2-propinylamin	Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-, (R)-
methyl(1-phenylpropan-2-yl)(prop-2-yn-1-yl)amine	Prestwick0_000552
Prestwick1_000552	Prestwick2_000552
Prestwick3_000552	Selegiline (USAN/INN)
SCHEMBL22232	US8633208, Deprenyl
BSPBio_000623	BSPBio_001589
SPBio_002544	BPBio1_000687
GTPL6639	DTXSID6023575
BDBM15579	Benzeneethanamine, N,alpha-methyl-N-2-propynyl-, (alphaR)-
HMS1791P11	HMS1989P11
HMS2089D09	HMS3402P11
(-)-(N)-Methyl-N-((1R)-1-methyl-2-phenylethyl)prop-2-yn-1-amine	STK640578
ZINC19632633	AKOS000281115
DB01037	NCGC00024994-01
NCGC00024994-02	NCGC00024994-03
NCGC00024994-04	C07245
D03731	(r)-(-)-n,2-dimethyl-n-2-propynylphenethylamine
BRD-K86434416-001-02-7	BRD-K86434416-003-03-1
BRD-K86434416-003-06-4	Q47495783
methyl(2R)-1-phenylpropan-2-ylprop-2-yn-1-ylamine	methyl(2R)-1-phenylpropan-2-yl(prop-2-yn-1-yl)amine
UNII-DPF682Q08V component MEZLKOACVSPNER-GFCCVEGCSA-N	UNII-DPF682Q08V component MEZLKOACVSPNER-LBPRGKRZSA-N
N-methyl-N-(1R)-1-methyl-2-phenylethylprop-2-yn-1-amine	102741-42-4
R(-)-Selegiline solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material

Experimental Data

selegiline

Species	Dosage	Unit	CG Lifespan(AVG/MED days)	TG Lifespan(AVG/MED days)	Lifespan Change(AVG/MED%)	CG Lifespan(MAX days)	TG Lifespan(MAX days)	Lifespan Change(MAX%)	Significant	Strain	Gender	PubMed	Active Label
Mesocricetus auratus	0.05	mg/kg				408	475	0.16	S			9258898
Rattus norvegicus	0.25	%	1147	1337	16.5				Unclear		MALES	2118586
Mus musculus	0.25	mg/kg	898	933	3.9				Unclear		FEMALES	8914495
Rattus norvegicus	0.5	mg/kg	874.3	919.6	5.18				Unclear			8423709
Mus musculus	0.25	mg/kg	950	949	-0.11				Unclear		FEMALES	8914495	Inactive
Rattus norvegicus	0.5	mg/kg	872.3	926.6	6.22				Unclear			8423709
Rattus norvegicus	0.5	mg			5.6				Unclear		MALES	8030852
Rattus norvegicus	0.5	mg/kg	885.8	932.4	5.26				Unclear			8423709
Mus musculus	0.25	mg/kg	1003	1073	6.98				Unclear		MALES	8914495
Mus musculus	0.25	mg/kg	1036	1054	1.74				Unclear		MALES	8914495

Experimental Data Visualization

selegiline

Statistics Data

selegiline

Species	Lifespan Change(AVG/MED%)	Lifespan Change(MAX%)	Count Reference	Count Data point
Mesocricetus auratus		0.16	1	1
Mus musculus	6.98		1	4
Rattus norvegicus	16.5		3	5

Statistics Data Visualization

selegiline