Compound Summary
Compound Information
cortisone
Compound Name: | cortisone |
Compound CID: | 222786 |
Synonyms: | cortisone 53-06-5 Kendalls compound E Andreson Cortisal More... |
Iupac Name: | (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione |
InChI: | InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 |
InChIKey: | MFYSYFVPBJMHGN-ZPOLXVRWSA-N |
Canonical Smiles: | CC12CCC(=O)C=C1CCC3C2C(=O)CC4(C3CCC4(C(=O)CO)O)C |
Isomeric Smiles: | C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C |
Molecular Weight: | 360.4 |
Molecular Formula: | C21H28O5 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
cortisone
Molecular Weight: | 360.4 |
Molecular Formula: | C21H28O5 |
Hydrogen Bond Donor Count: | 2 |
Hydrogen Bond Acceptor Count: | 5 |
Rotatable Bond Count: | 2 |
Heavy Atom Count: | 26 |
Complexity: | 724 |
Synonyms
cortisone
| cortisone | cortisone |
|---|---|
cortisone |
53-06-5 |
Kendalls compound E |
Andreson |
Cortisal |
Cortisate |
Cortistal |
Cortivite |
Cortogen |
Cortone |
Reichsteins substance FA |
Adrenalex |
Reichstein Fa |
Wintersteiners compound F |
11-Dehydro-17-hydroxycorticosterone |
17-Hydroxy-11-dehydrocorticosterone |
Cortandren |
Cortisona |
Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy- |
4-Pregnene-17alpha,21-diol-3,11,20-trione |
Cortison |
Kortison |
17alpha-Hydroxy-11-dehydrocorticosterone |
17alpha,21-Dihydroxypregn-4-ene-3,11,20-trione |
NSC 9703 |
Kendalls compound |
17,21-Dihydroxypregn-4-ene-3,11,20-trione |
3H-cortisone |
Prestwick_132 |
UNII-V27W9254FZ |
Pregn-4-en-17alpha,21-diol-3,11,20-trione |
17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione |
KE |
delta(sup4)-pregnene-17alpha,21-diol-3,11,20-trione |
MLS000028540 |
CHEBI:16962 |
3Hcortisone |
NSC9703 |
V27W9254FZ |
MFCD00003610 |
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopentaaphenanthrene-3,11-dione |
SMR000058334 |
17.alpha.-Hydroxy-11-dehydrocorticosterone |
DSSTox_CID_2857 |
DSSTox_RID_76760 |
DSSTox_GSID_22857 |
Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy |
Cortisonum |
Cortisone INN:BAN |
Cortisonum INN-Latin |
Cortisona INN-Spanish |
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo8.7.0.0^{2,7}.0^{11,15}heptadec-6-ene-5,17-dione |
EINECS 200-162-4 |
AI3-52938 |
CAS-53-06-5 |
Cortisone (TN) |
Cortisone (INN) |
NCGC00095935-01 |
Kendalls Compound E |
Corlin (Salt/Mix) |
Cortelan (Salt/Mix) |
Ricortex (Salt/Mix) |
(non-d)Cortisone-d2 |
Cortadren (Salt/Mix) |
Scheroson (Salt/Mix) |
Cortisone, >=98% |
Opera_ID_541 |
Reichsteins Substance Fa |
Prestwick0_000273 |
Prestwick1_000273 |
Prestwick2_000273 |
Prestwick3_000273 |
Spectrum5_002051 |
bmse000663 |
SCHEMBL4888 |
CHEMBL1499 |
Lopac0_000240 |
BSPBio_000146 |
MLS001076142 |
MLS001424269 |
MLS002207137 |
17.alpha.,11,20-trione |
SPBio_002365 |
BPBio1_000162 |
GTPL5171 |
DTXSID5022857 |
BDBM13739 |
Cortisone 0.1 mg/ml in Methanol |
HMS1568H08 |
HMS2052A21 |
HMS2095H08 |
HMS2235P19 |
HMS3260P21 |
HMS3712H08 |
ZINC4083557 |
Tox21_111539 |
Tox21_301440 |
Tox21_500240 |
LMST02030090 |
s5869 |
AKOS015840096 |
AKOS015894868 |
Tox21_111539_1 |
ACN-053277 |
CCG-101143 |
CS-5097 |
DB14681 |
LP00240 |
NC00393 |
SDCCGSBI-0050228.P002 |
4-Pregnene-17.alpha.,11,20-trione |
NCGC00023939-03 |
NCGC00023939-04 |
NCGC00023939-05 |
NCGC00023939-06 |
NCGC00023939-07 |
NCGC00023939-08 |
NCGC00023939-09 |
NCGC00023939-11 |
NCGC00023939-15 |
NCGC00255108-01 |
NCGC00260925-01 |
Pregn-4-en-17.alpha.,11,20-trione |
AC-33118 |
AS-11686 |
HY-17461 |
NCI60_042165 |
EU-0100240 |
2708-EP2269977A2 |
2708-EP2272834A1 |
2708-EP2292228A1 |
2708-EP2295411A1 |
2708-EP2298747A1 |
2708-EP2301929A1 |
2708-EP2301935A1 |
2708-EP2305674A1 |
2708-EP2308851A1 |
2708-EP2311811A1 |
2708-EP2314585A1 |
C 2755 |
C00762 |
D07749 |
D96089 |
Pregn-4-ene-3,20-trione, 17,21-dihydroxy- |
10841-EP2280008A2 |
10841-EP2298767A1 |
10841-EP2301536A1 |
10841-EP2301538A1 |
10841-EP2311455A1 |
10841-EP2314587A1 |
10841-EP2316452A1 |
.delta.(sup4)-pregnene-17.alpha.,11,20-trione |
17??,21-Dihydroxypregn-4-ene-3,11,20-trione |
4-Pregnene-17.alpha.,21-diol-3,11,20-trione |
Q423185 |
SR-01000000094 |
Pregn-4-en-17.alpha.,21-diol-3,11,20-trione |
SR-01000000094-3 |
W-105776 |
17.alpha.,21-Dihydroxy-4-pregnene-3,11,20-trione |
BRD-K43736954-001-03-3 |
Cortisone, certified reference material, TraceCERT(R) |
Delta(4)-pregnene-17alpha,21-diol-3,11,20-trione |
WLN: L E5 B666 CV OV MUTJ A1 E1 FV1Q FQ |
.DELTA.4-pregnene-17.alpha.,21-diol-3,11,20-trione |
17.alpha.,21.beta.-Dihydroxypregn-4-ene-3,11,20-trione |
(10R,13S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopentaaphenanthrene-3,11-dione |
Kendalls Compound E; 4-Pregnene-17alpha,21-diol-3,11,20-trione; Reichsteins Substance Fa" |
Experimental Data
cortisone
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asplanchna brightwellii | 50 | umol/L | 5.38 | 5.5 | 2.2 | Unclear | clone 4B61 | 2782995 | |||||
| Asplanchna brightwellii | 10 | umol/L | 5.38 | 5.42 | 0.7 | Unclear | clone 4B61 | 2782995 | |||||
| Asplanchna brightwellii | 400 | umol/L | 5.38 | 5.21 | -3.1 | Unclear | clone 4B61 | 2782995 | Inactive | ||||
| Asplanchna brightwellii | 800 | umol/L | 5.38 | 5.04 | -6.3 | Unclear | clone 4B61 | 2782995 | Inactive | ||||
| Asplanchna brightwellii | 100 | umol/L | 5.38 | 6.5 | 20.8 | Unclear | clone 4B61 | 2782995 | |||||
| Asplanchna brightwellii | 200 | umol/L | 5.38 | 6.42 | 19.3 | Unclear | clone 4B61 | 2782995 | |||||
| Caenorhabditis elegans | 33 | umol/L | -2 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
cortisone
Statistics Data
cortisone
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Asplanchna brightwellii | 20.8 | 1 | 6 | |
| Caenorhabditis elegans | -2 | 1 | 1 |
Statistics Data Visualization
cortisone
