Compound Summary
Compound Information
amoxapine
Compound Name: | amoxapine |
Compound CID: | 2170 |
Synonyms: | amoxapine 14028-44-5 Asendin Demolox Moxadil More... |
Iupac Name: | 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine |
InChI: | InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2 |
InChIKey: | QWGDMFLQWFTERH-UHFFFAOYSA-N |
Canonical Smiles: | C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl |
Isomeric Smiles: | C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl |
Molecular Weight: | 313.8 |
Molecular Formula: | C17H16ClN3O |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
amoxapine
Molecular Weight: | 313.8 |
Molecular Formula: | C17H16ClN3O |
Hydrogen Bond Donor Count: | 1 |
Hydrogen Bond Acceptor Count: | 3 |
Rotatable Bond Count: | 1 |
Heavy Atom Count: | 22 |
Complexity: | 424 |
Synonyms
amoxapine
| amoxapine | amoxapine |
|---|---|
amoxapine |
14028-44-5 |
Asendin |
Demolox |
Moxadil |
Amoxan |
Desmethylloxapin |
Amoxapina |
Amoxapinum |
Amoxepine |
Dibenzb,f1,4oxazepine, 2-chloro-11-(1-piperazinyl)- |
CL-67772 |
2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine |
8-chloro-6-piperazin-1-ylbenzob1,4benzoxazepine |
CL 67772 |
UNII-R63VQ857OT |
2-chloro-11-(piperazin-1-yl)dibenzob,f1,4oxazepine |
Asendis |
MFCD00069210 |
CHEMBL1113 |
2-Chloro-11-(1-piperazinyl)dibenzb,f1,4oxazepine |
CL 67,772 |
MLS000069371 |
CHEBI:2675 |
R63VQ857OT |
DIBENZ(b,f)(1,4)OXAZEPINE, 2-CHLORO-11-(1-PIPERAZINYL)- |
2-chloro-11-piperazin-1-yldibenzob,f1,4oxazepine |
NCGC00015004-09 |
Ascendin |
SMR000058416 |
CAS-14028-44-5 |
DSSTox_CID_2598 |
Amoxapinum INN-Latin |
DSSTox_RID_76652 |
Amoxapina INN-Spanish |
DSSTox_GSID_22598 |
13-chloro-10-(piperazin-1-yl)-2-oxa-9-azatricyclo9.4.0.0^{3,8}pentadeca-1(11),3(8),4,6,9,12,14-heptaene |
(E)-2-chloro-11-(piperazin-1-yl)dibenzob,f1,4oxazepine |
Asendin (TN) |
SR-01000003001 |
EINECS 237-867-1 |
amoxipine |
BRN 0832057 |
2-Chlor-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepin |
Amoxapine-d8 |
Prestwick_503 |
Amoxapine USAN:USP:INN:BAN:JAN |
KS-1197 |
2-Chloro-11-(1-piperazinyl)dibenzob,f1,4oxazepine |
Opera_ID_33 |
Spectrum_000446 |
CPD000058416 |
Lopac-A-129 |
Prestwick0_000102 |
Prestwick1_000102 |
Prestwick2_000102 |
Prestwick3_000102 |
Spectrum2_001245 |
Spectrum3_001067 |
Spectrum4_001218 |
Spectrum5_001284 |
A-129 |
Lopac0_000116 |
REGID_for_CID_2170 |
SCHEMBL33950 |
BSPBio_000084 |
BSPBio_002654 |
GTPL201 |
KBioGR_001656 |
KBioSS_000926 |
ZINC931 |
MALEICACIDMONOSODIUMSALT |
DivK1c_000236 |
SPECTRUM2300161 |
SPBio_001150 |
SPBio_002023 |
Amoxapine (JP17/USP/INN) |
BPBio1_000094 |
8-chloro-6-piperazin-1-yl-benzob1,4benzoxazepine |
DTXSID7022598 |
BDBM22870 |
HMS500L18 |
KBio1_000236 |
KBio2_000926 |
KBio2_003494 |
KBio2_006062 |
KBio3_001874 |
NINDS_000236 |
HMS1568E06 |
HMS2089G10 |
HMS2093N08 |
HMS2095E06 |
HMS2231E13 |
HMS3259G08 |
HMS3260G14 |
HMS3370P03 |
HMS3712E06 |
Pharmakon1600-02300161 |
HY-B0991 |
Tox21_110064 |
Tox21_302352 |
Tox21_500116 |
CCG-39135 |
NSC759559 |
PDSP1_001609 |
PDSP2_001593 |
s4218 |
AKOS015895092 |
Tox21_110064_1 |
AC-5495 |
CS-4485 |
DB00543 |
LP00116 |
MCULE-9583761109 |
NC00546 |
NSC 759559 |
NSC-759559 |
SDCCGSBI-0050104.P004 |
VA10272 |
IDI1_000236 |
NCGC00015004-01 |
NCGC00015004-02 |
NCGC00015004-03 |
NCGC00015004-04 |
NCGC00015004-05 |
NCGC00015004-06 |
NCGC00015004-07 |
NCGC00015004-08 |
NCGC00015004-10 |
NCGC00015004-11 |
NCGC00015004-13 |
NCGC00015004-16 |
NCGC00015004-22 |
NCGC00023887-03 |
NCGC00023887-04 |
NCGC00023887-05 |
NCGC00023887-06 |
NCGC00255124-01 |
NCGC00260801-01 |
BA164170 |
O286 |
SBI-0050104.P003 |
EU-0100116 |
FT-0659871 |
FT-0662122 |
A16406 |
D00228 |
Q58356 |
T70258 |
AB00052421-13 |
AB00052421_14 |
AB00052421_15 |
028A445 |
A807639 |
L001293 |
J-007373 |
SR-01000003001-2 |
SR-01000003001-4 |
SR-01000003001-6 |
8-chloro-6-piperazin-1-ylbenzob1,5benzoxazepine |
BRD-K02265150-001-05-9 |
BRD-K02265150-001-15-8 |
2-Chloro-11-(1-piperazinyl)dibenzb,f-1,4-oxazepine |
2-Chloro-11-(1-piperazinyl)dibenzob,f-1,4-oxazepine |
2-Chloro-11-piperazin-1-yl-dibenzob,f1,4oxazepine |
8-chloro-6-(1-piperazinyl)benzob1,4benzoxazepine |
Z1551429736 |
2-Chloro-11-(1-piperazinyl)dibenzob,f1,4oxazepine # |
8-chloranyl-6-piperazin-1-yl-benzob1,4benzoxazepine |
Amoxapine, 1.0 mg/mL in methanol, certified reference material |
Amoxapine, United States Pharmacopeia (USP) Reference Standard |
Dibenzob,f1,4oxazepine, 2-chloro-11-(1-piperazinyl)- |
Amoxapine, Pharmaceutical Secondary Standard; Certified Reference Material |
13-chloro-10-(piperazin-1-yl)-2-oxa-9-azatricyclo9.4.0.0^{3,8}pentadeca-1(11),3,5,7,9,12,14-heptaene |
Experimental Data
amoxapine
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33 | umol/L | 33 | S | N2 | 33683565 | Active | ||||||
| Caenorhabditis elegans | 88 | umol/L | 33 | S | N2 | 24134630 | Active | ||||||
| Drosophila melanogaster | 20 | umol/L | 47.84 | 47.8 | -0.09 | NS | FEMALES | 33008901 | Inactive | ||||
| Drosophila melanogaster | 200 | umol/L | 44.01 | 42.67 | -3.035 | NS | MALES | 33008901 | Inactive | ||||
| Drosophila melanogaster | 200 | umol/L | 43.13 | 46.07 | 6.83 | S | MALES | 33008901 | Active | ||||
| Drosophila melanogaster | 20 | umol/L | 48.86 | 48.86 | 0.002968 | NS | FEMALES | 33008901 | Inactive |
Experimental Data Visualization
amoxapine
Statistics Data
amoxapine
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 33 | 2 | 2 | |
| Drosophila melanogaster | 6.83 | 1 | 4 |
Statistics Data Visualization
amoxapine
