Compound Summary
Compound Information
6,5-dichloroindirubin
Compound Name: | 6,5-dichloroindirubin |
Compound CID: | 135421131 |
Synonyms: | indirubin deriv. 5e 6,5-dichloroindirubin BDBM7423 CHEMBL367664 (2 Z)-5,6-Dichloroindirubin More... |
Iupac Name: | 2-(5,6-dichloro-2-hydroxy-1H-indol-3-yl)indol-3-one |
InChI: | InChI=1S/C16H8Cl2N2O2/c17-9-5-8-12(6-10(9)18)20-16(22)13(8)14-15(21)7-3-1-2-4-11(7)19-14/h1-6,20,22H |
InChIKey: | OVYJVQMDQIHIRD-UHFFFAOYSA-N |
Canonical Smiles: | C1=CC=C2C(=C1)C(=O)C(=N2)C3=C(NC4=CC(=C(C=C43)Cl)Cl)O |
Isomeric Smiles: | C1=CC=C2C(=C1)C(=O)C(=N2)C3=C(NC4=CC(=C(C=C43)Cl)Cl)O |
Molecular Weight: | 331.1 |
Molecular Formula: | C16H8Cl2N2O2 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
6,5-dichloroindirubin
Molecular Weight: | 331.1 |
Molecular Formula: | C16H8Cl2N2O2 |
Hydrogen Bond Donor Count: | 2 |
Hydrogen Bond Acceptor Count: | 3 |
Rotatable Bond Count: | 1 |
Heavy Atom Count: | 22 |
Complexity: | 512 |
Synonyms
6,5-dichloroindirubin
| 6,5-dichloroindirubin | 6,5-dichloroindirubin |
|---|---|
indirubin deriv. 5e |
6,5-dichloroindirubin |
BDBM7423 |
CHEMBL367664 |
(2 Z)-5,6-Dichloroindirubin |
CHEMBL4065106 |
SCHEMBL20714350 |
SCHEMBL21856626 |
SCHEMBL21856627 |
5,6-dichloro-3-(2Z)-3-oxo-2,3-dihydro-1H-indol-2-ylidene-2,3-dihydro-1H-indol-2-one |
Experimental Data
6,5-dichloroindirubin
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | 800 | umol/L | 20 | 20 | 0 | 39 | 43 | 0.1 | NS | w1118 | 28253732 | Inactive | |
| Drosophila melanogaster | 600 | umol/L | 24 | 24 | 20 | 39 | 42 | 0.08 | S | w1118 | 28253732 | Active | |
| Drosophila melanogaster | 400 | umol/L | 20 | 19 | -5 | 39 | 49 | 0.26 | NS | w1118 | 28253732 | Inactive |
Experimental Data Visualization
6,5-dichloroindirubin
Statistics Data
6,5-dichloroindirubin
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Drosophila melanogaster | 20 | 0.26 | 1 | 3 |
Statistics Data Visualization
6,5-dichloroindirubin
