Compound Summary
Compound Information
clozapine
Compound Name: | clozapine |
Compound CID: | 135398737 |
Synonyms: | clozapine 5786-21-0 Leponex Clozapin CLOZARIL More... |
Iupac Name: | 3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine |
InChI: | InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 |
InChIKey: | QZUDBNBUXVUHMW-UHFFFAOYSA-N |
Canonical Smiles: | CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42 |
Isomeric Smiles: | CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42 |
Molecular Weight: | 326.8 |
Molecular Formula: | C18H19ClN4 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
clozapine
Molecular Weight: | 326.8 |
Molecular Formula: | C18H19ClN4 |
Hydrogen Bond Donor Count: | 1 |
Hydrogen Bond Acceptor Count: | 3 |
Rotatable Bond Count: | 1 |
Heavy Atom Count: | 23 |
Complexity: | 446 |
Synonyms
clozapine
| clozapine | clozapine |
|---|---|
clozapine |
5786-21-0 |
Leponex |
Clozapin |
CLOZARIL |
Fazaclo |
Clorazil |
Iprox |
Clozapina |
Clozapinum |
HF 1854 |
HF-1854 |
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzob,e1,4diazepine |
W-801 |
8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzob,e1,4diazepine |
UNII-J60AR2IKIC |
5H-Dibenzob,e1,4diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)- |
C18H19ClN4 |
3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzob1,4benzodiazepine |
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine |
LX 100-129 |
CHEMBL42 |
MFCD00153785 |
J60AR2IKIC |
Clozapine resolution mixture |
5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)- |
MLS000028472 |
CHEBI:3766 |
Asaleptin |
Lepotex |
Fazaclo ODT |
NCGC00015254-12 |
SMR000058365 |
CAS-5786-21-0 |
3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzob1,4benzodiazepine |
8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzob,e1,4diazepine |
DSSTox_CID_2855 |
Clozapinum INN-Latin |
DSSTox_RID_76759 |
Clozapina INN-Spanish |
DSSTox_GSID_22855 |
Azaleptine |
Versacloz |
Clozaril (TN) |
6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo9.4.0.0^{3,8}pentadeca-1,3(8),4,6,10,12,14-heptaene |
CCRIS 9171 |
HSDB 6478 |
SR-01000000096 |
EINECS 227-313-7 |
BRN 0764984 |
Clozapine (JAN/USP/INN) |
Clozapine, solid |
Clozapine solution |
LEX-123 |
Clozapine USAN:USP:INN:BAN |
Prestwick_693 |
Clozapine - Bio-X |
Clozapine (Clozaril) |
KS-1166 |
Spectrum_000139 |
Tocris-0444 |
CPD000058365 |
Opera_ID_482 |
Prestwick0_000350 |
Prestwick1_000350 |
Spectrum2_000919 |
Spectrum3_001828 |
Spectrum4_000898 |
Lopac-C-6305 |
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzob,e1,4-diazepine |
GTPL38 |
C 6305 |
SCHEMBL8397 |
REGID_for_CID_2818 |
SCHEMBL33323 |
KBioGR_000310 |
KBioGR_001336 |
KBioSS_000310 |
KBioSS_000599 |
MLS001077282 |
DivK1c_000343 |
SPECTRUM1500685 |
SPBio_000798 |
SPBio_002340 |
DTXSID5022855 |
BDBM22869 |
CHEBI:92657 |
HMS501B05 |
KBio1_000343 |
KBio2_000310 |
KBio2_000599 |
KBio2_002878 |
KBio2_003167 |
KBio2_005446 |
KBio2_005735 |
KBio3_000619 |
KBio3_000620 |
KBio3_002979 |
AOB5635 |
NINDS_000343 |
Bio1_000436 |
Bio1_000925 |
Bio1_001414 |
Bio2_000310 |
Bio2_000790 |
HMS1361P12 |
HMS1569E21 |
HMS1791P12 |
HMS1921C16 |
HMS1989P12 |
HMS2089L13 |
HMS2092I16 |
HMS2096E21 |
HMS2235E19 |
HMS3259J17 |
HMS3260H14 |
HMS3266A10 |
HMS3371H05 |
HMS3402P12 |
HMS3414F09 |
HMS3657E15 |
HMS3678F09 |
HMS3713E21 |
HMS3742K03 |
Pharmakon1600-01500685 |
BCP25196 |
ZINC3872123 |
Tox21_110113 |
Tox21_500276 |
BDBM50001884 |
CC0176 |
CCG-39881 |
NSC757429 |
s2459 |
ZINC19796155 |
Clozapine 1.0 mg/ml in Acetonitrile |
8-Chloro-11-(4-methyl)-1-piperazinyl)-5H-dibenzob,e1,4diazepine |
AKOS005064444 |
AKOS026749900 |
Tox21_110113_1 |
CS-0644 |
DB00363 |
LP00276 |
MCULE-3665900006 |
NC00667 |
NSC 757429 |
NSC-757429 |
SDCCGSBI-0050264.P005 |
NCGC00015254-01 |
NCGC00015254-02 |
NCGC00015254-03 |
NCGC00015254-04 |
NCGC00015254-05 |
NCGC00015254-06 |
NCGC00015254-07 |
NCGC00015254-08 |
NCGC00015254-09 |
NCGC00015254-10 |
NCGC00015254-11 |
NCGC00015254-13 |
NCGC00015254-14 |
NCGC00015254-15 |
NCGC00015254-16 |
NCGC00015254-17 |
NCGC00015254-18 |
NCGC00015254-20 |
NCGC00015254-31 |
NCGC00022902-02 |
NCGC00022902-04 |
NCGC00022902-05 |
NCGC00022902-06 |
NCGC00022902-07 |
NCGC00022902-08 |
NCGC00022902-09 |
NCGC00022902-10 |
NCGC00022902-11 |
NCGC00022902-12 |
NCGC00022902-13 |
NCGC00188978-01 |
NCGC00260961-01 |
BC164328 |
H482 |
HY-14539 |
SBI-0050264.P004 |
AB0013069 |
DB-053121 |
D-107 |
EU-0100276 |
SW220247-1 |
EN300-52510 |
C06924 |
D00283 |
H10436 |
AB00052158-13 |
AB00052158-14 |
AB00052158_15 |
AB00052158_16 |
786C210 |
Clozapine, drug standard, 1.0 mg/mL in methanol |
L000195 |
L013417 |
Q221361 |
SR-01000000096-2 |
SR-01000000096-4 |
SR-01000000096-5 |
SR-01000000096-8 |
W-105432 |
BRD-K37289225-001-09-1 |
BRD-K37289225-001-23-2 |
Clozapine, British Pharmacopoeia (BP) Reference Standard |
Z1245633277 |
Clozapine, European Pharmacopoeia (EP) Reference Standard |
Clozapine, United States Pharmacopeia (USP) Reference Standard |
8-Chloro-11-(4-methylpiperazino)-5H-dibenzob,e1,4diazepine |
(E)-8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzob,e1,4diazepine |
3-chloro-6-(4-methyl-piperazin-1-yl)-5H-dibenzob,e1,4diazepine |
8-chloro-11-(4-methyl-piperazin-1-yl)-10H-dibenzob,e1,4diazepine |
3-Hydroxy-2-phenyl-propionic acid 8-methyl-8-aza-bicyclo3.2.1oct-3-yl ester |
8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzob,e1,4diazepine (Clozapine) |
8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzob,e1,4diazepine( Clozepine ) |
8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzob,e1,4diazepine(Ciozapine) |
8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzob,e1,4diazepine(Clopazine) |
Clozapine for peak identification, European Pharmacopoeia (EP) Reference Standard |
Clozapine Resolution Mixture, United States Pharmacopeia (USP) Reference Standard |
Clozapine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material |
CLOZAPINE, 8-CHLORO-11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZOB,E1,4DIAZEPINE |
1333667-72-3 |
6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo9.4.0.03,8pentadeca-1(11),3,5,7,9,12,14-heptaene |
Experimental Data
clozapine
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33 | umol/L | 19 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
clozapine
Statistics Data
clozapine
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 19 | 1 | 1 |
Statistics Data Visualization
clozapine
