Compound Summary
Compound Information
PAPP
Compound Name: | PAPP |
Compound CID: | 121930 |
Synonyms: | PAPP 1814-64-8 LY 165163 LY-165,163 LY-165163 More... |
Iupac Name: | 4-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]aniline |
InChI: | InChI=1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2 |
InChIKey: | GAAKALASJNGQKD-UHFFFAOYSA-N |
Canonical Smiles: | C1CN(CCN1CCC2=CC=C(C=C2)N)C3=CC=CC(=C3)C(F)(F)F |
Isomeric Smiles: | C1CN(CCN1CCC2=CC=C(C=C2)N)C3=CC=CC(=C3)C(F)(F)F |
Molecular Weight: | 349.4 |
Molecular Formula: | C19H22F3N3 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
PAPP
Molecular Weight: | 349.4 |
Molecular Formula: | C19H22F3N3 |
Hydrogen Bond Donor Count: | 1 |
Hydrogen Bond Acceptor Count: | 6 |
Rotatable Bond Count: | 4 |
Heavy Atom Count: | 25 |
Complexity: | 399 |
Synonyms
PAPP
| PAPP | PAPP |
|---|---|
PAPP |
1814-64-8 |
LY 165163 |
LY-165,163 |
LY-165163 |
UNII-8HAJ699EWG |
4-2-4-3-(Trifluoromethyl)phenylpiperazin-1-ylethylaniline |
8HAJ699EWG |
LY 165,163 |
p-NH2-PE-Tfmpp |
NSC628235 |
Lopac-S-009 |
1-(2-(4-Aminophenyl)ethyl)-4-(3-trifluoromethylphenyl)piperazine |
Biomol-NT_000160 |
GTPL18 |
Lopac0_001132 |
MLS000859974 |
p-Aminophenethyl-m-trifluoromethylphenyl piperazine |
LY-165,163, solid |
BPBio1_000375 |
SCHEMBL3976547 |
CHEMBL1256693 |
CHEBI:92250 |
DTXSID30171136 |
HMS2232I03 |
HMS3263D05 |
HMS3369D03 |
ZINC1619831 |
Tox21_501132 |
4-2-4-3-(Trifluoromethyl)phenyl-1-piperazinylethylbenzeneamine |
MFCD00055098 |
Benzenamine, 4-(2-(4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)ethyl)- |
CCG-205206 |
LP01132 |
SDCCGSBI-0051099.P002 |
NCGC00015907-01 |
NCGC00015907-02 |
NCGC00015907-03 |
NCGC00015907-04 |
NCGC00015907-05 |
NCGC00015907-08 |
NCGC00094399-01 |
NCGC00094399-02 |
NCGC00094399-03 |
NCGC00261817-01 |
NCI60_009079 |
SMR000326833 |
DB-090559 |
LY165,163 |
EU-0101132 |
S-009 |
SR-01000075576 |
J-011585 |
SR-01000075576-1 |
BRD-K14282469-001-01-5 |
PAPP (LY-165,163) SELECTIVE 5-HT1A SERO |
Q27082543 |
LY-165,163; p-Aminophenethyl-m-trifluoromethylphenyl piperazine |
4-(2-(4-(3-(Trifluoromethyl)phenyl)-1-piperazinyl)ethyl)-Benzenamine |
4-(2-(4-(3-(Trifluoromethyl)phenyl)-1-piperazinyl)ethyl)aniline hydrochloride |
Experimental Data
PAPP
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33 | umol/L | 33 | S | N2 | 24134630 | Active | ||||||
| Drosophila melanogaster | 200 | umol/L | 47.16 | 50.48 | 7.04 | NS | MALES | 33008901 | Inactive | ||||
| Drosophila melanogaster | 20 | umol/L | 52.83 | 55.85 | 5.71 | S | FEMALES | 33008901 | Active | ||||
| Caenorhabditis elegans | 33 | umol/L | 23 | NS | N2 | 24134630 | Inactive | ||||||
| Caenorhabditis elegans | 33 | umol/L | 33 | S | N2 | 33683565 | Active |
Experimental Data Visualization
PAPP
Statistics Data
PAPP
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 33 | 2 | 3 | |
| Drosophila melanogaster | 7.04 | 1 | 2 |
Statistics Data Visualization
PAPP
