Compound Summary
Compound Information
NAFTOPIDIL DIHYDROCHLORIDE
Compound Name: | NAFTOPIDIL DIHYDROCHLORIDE |
Compound CID: | 11957660 |
Synonyms: | NAFTOPIDIL DIHYDROCHLORIDE 57149-08-3 Naftopidil DiHCl Naftopidil (dihydrochloride) Avishot More... |
Iupac Name: | 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol;dihydrochloride |
InChI: | InChI=1S/C24H28N2O3.2ClH/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23;;/h2-12,20,27H,13-18H2,1H3;2*1H |
InChIKey: | HZVCEQMJXMUXJF-UHFFFAOYSA-N |
Canonical Smiles: | COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O.Cl.Cl |
Isomeric Smiles: | COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O.Cl.Cl |
Molecular Weight: | 465.4 |
Molecular Formula: | C24H30Cl2N2O3 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
NAFTOPIDIL DIHYDROCHLORIDE
Molecular Weight: | 465.4 |
Molecular Formula: | C24H30Cl2N2O3 |
Hydrogen Bond Donor Count: | 3 |
Hydrogen Bond Acceptor Count: | 5 |
Rotatable Bond Count: | 7 |
Heavy Atom Count: | 31 |
Complexity: | 483 |
Synonyms
NAFTOPIDIL DIHYDROCHLORIDE
| NAFTOPIDIL DIHYDROCHLORIDE | NAFTOPIDIL DIHYDROCHLORIDE |
|---|---|
NAFTOPIDIL DIHYDROCHLORIDE |
57149-08-3 |
Naftopidil DiHCl |
Naftopidil (dihydrochloride) |
Avishot |
Flivas |
1-(4-(2-methoxyphenyl)piperazin-1-yl)-3-(naphthalen-1-yloxy)propan-2-ol dihydrochloride |
Naftopidil 2HCl |
1-4-(2-methoxyphenyl)piperazin-1-yl-3-naphthalen-1-yloxypropan-2-ol;dihydrochloride |
KT-611;BM-15275 |
C24H30Cl2N2O3 |
1-4-(2-methoxyphenyl)-1-piperazinyl-3-(1-naphthoxy)-2-propanol dihydrochloride |
SR-01000002977 |
Naftopidil dihydrochloride MI |
Naftopidil dihydrochloride, (+/-)- |
KT-611 dihydrochloride |
Naftopidil.Dihydrochloride |
EU-0100941 |
KT-611 2HCl |
SCHEMBL1322047 |
CHEMBL1593765 |
HY-B0391A |
HMS1571C11 |
Tox21_500941 |
s1387 |
AKOS015900296 |
CCG-220975 |
CCG-222245 |
FE-0212 |
LP00941 |
MCULE-7806634031 |
4-(2-Methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-piperazineethanol dihydrochloride |
NCGC00094247-01 |
NCGC00261626-01 |
1-Piperazineethanol, 4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-, hydrochloride (1:2) |
AC-24018 |
CS-0019738 |
FT-0672587 |
N-158 |
SW196570-5 |
VU0612514-1 |
A50003 |
C75677 |
M02151 |
149N072 |
A913228 |
SR-01000002977-2 |
SR-01000002977-4 |
Q27264951 |
SR-01000002977-10 |
SR-01000002977-11 |
F3368-0103 |
4-(2-Methoxyphenyl)-a-(1-naphthalenyloxy)methyl-1-piperazineethanol,2HCl |
1-4-(2-Methoxyphenyl)-1-piperazinyl-3-(1-naphthyloxy)-2-propanol dihydrochloride |
Experimental Data
NAFTOPIDIL DIHYDROCHLORIDE
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33 | umol/L | 14 | NS | N2 | 24134630 | Inactive | ||||||
| Caenorhabditis elegans | 33 | umol/L | 14 | S | N2 | 24134630 | Active | ||||||
| Caenorhabditis elegans | 33 | umol/L | 14 | S | N2 | 33683565 | Active |
Experimental Data Visualization
NAFTOPIDIL DIHYDROCHLORIDE
Statistics Data
NAFTOPIDIL DIHYDROCHLORIDE
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 14 | 2 | 3 |
Statistics Data Visualization
NAFTOPIDIL DIHYDROCHLORIDE
