Compound Summary
Compound Information
Trametinib
Compound Name: | Trametinib |
Compound CID: | 11707110 |
Synonyms: | Trametinib 871700-17-3 GSK1120212 Mekinist GSK-1120212 More... |
Iupac Name: | N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide |
InChI: | InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34) |
InChIKey: | LIRYPHYGHXZJBZ-UHFFFAOYSA-N |
Canonical Smiles: | CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5 |
Isomeric Smiles: | CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5 |
Molecular Weight: | 615.4 |
Molecular Formula: | C26H23FIN5O4 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
Trametinib
Molecular Weight: | 615.4 |
Molecular Formula: | C26H23FIN5O4 |
Hydrogen Bond Donor Count: | 2 |
Hydrogen Bond Acceptor Count: | 6 |
Rotatable Bond Count: | 5 |
Heavy Atom Count: | 37 |
Complexity: | 1090 |
Synonyms
Trametinib
| Trametinib | Trametinib |
|---|---|
Trametinib |
871700-17-3 |
GSK1120212 |
Mekinist |
GSK-1120212 |
JTP 74057 |
JTP-74057 |
GSK 1120212 |
Trametinib (GSK1120212) |
N-3-3-Cyclopropyl-5-(2-fluoro-4-iodophenyl)amino-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido4,3-dpyrimidin-1(2H)-ylphenylacetamide |
GSK212 |
UNII-33E86K87QN |
TMT212 |
CHEBI:75998 |
TMT-212 |
33E86K87QN |
N-(3-{3-cyclopropyl-5-(2-fluoro-4-iodophenyl)amino-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido4,3-dpyrimidin-1(2H)-yl}phenyl)acetamide |
N-3-3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido4,3-dpyrimidin-1-ylphenylacetamide |
Trametinib USAN:INN |
trametinibum |
JTP74057 |
N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7- tetrahydropyrido(4,3-d)pyrimidin-1(2H)-yl)phenyl)acetamide |
N-(3-{3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7- tetrahydropyrido(4,3-d)pyrimidin-1(2H)-yl}phenyl)acetamide |
QOM |
Trametinib (USAN) |
Trametinib (GSK1120212JTP 74057) |
cc-37 |
SCHEMBL170938 |
C26H23FIN5O4 |
GTPL6495 |
QCR-39 |
GSK1120212 (Trametinib) |
CHEMBL2103875 |
EX-A022 |
BCPP000218 |
DTXSID901007381 |
HMS3295I05 |
HMS3656J11 |
AOB87707 |
BCP02307 |
BDBM50531540 |
MFCD17215075 |
NSC758246 |
NSC800956 |
s2673 |
ZINC43100709 |
AKOS015850628 |
AM90271 |
CCG-264976 |
CS-0060 |
DB08911 |
EX-5957 |
NSC-758246 |
NSC-800956 |
SB16553 |
NCGC00263180-01 |
NCGC00263180-07 |
NCGC00263180-14 |
AC-25891 |
AS-19382 |
HY-10999 |
N-3-3-cyclopropyl-5-(2-fluoro-4-iodo-anilino)-6,8-dimethyl-2,4,7-trioxo-pyrido4,3-dpyrimidin-1-ylphenylacetamide |
AB0008115 |
FT-0688438 |
SW218089-2 |
X7454 |
A25168 |
D10175 |
GSK1120212 - JTP-74057 |
GSK1120212,JTP-74057, GSK212 |
SR-01000941589 |
A1-01871 |
J-523325 |
Q7833138 |
SR-01000941589-1 |
BRD-K12343256-001-01-4 |
Acetamide, N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-3,4,6,7-tetrahydro-6,8- dimethyl-2,4,7-trioxopyrido(4,3-d)pyrimidin-1(2H)-yl)phenyl)- |
Acetamide, N-3-3-cyclopropyl-5-(2-fluoro-4-iodophenyl)amino-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido4,3-dpyrimidin-1(2H)-ylphenyl- |
N-(3-(3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido4,3-dpyrimidin-1(2H)-yl)phenyl)acetamide |
N-3-3-Cyclopropyl-5-(2-Fluoro-4-Iodophenyl)amino-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido4,3-dpyrimidin-1(2h)-ylphe nylacetamide |
N-3-3-cyclopropyl-5-(2-fluoro-4-iodophenyl)amino-6,8-dimethyl-2,4,7-trioxopyrido3,4-epyrimidin-1-ylphenylacetamide |
N-{3-3-Cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido4,3-dpyrimidin-1(2H)-ylphenyl}ethanimidic acid |
N-{3-3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido4,3-dpyrimidin-1-ylphenyl}acetamide |
Experimental Data
Trametinib
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | 15.6 | umol/L | 73 | 82 | 12 | S | white Dahomey | 26119340 | Active | ||||
| Drosophila melanogaster | 1.56 | umol/L | 73 | 79 | 8 | S | white Dahomey | 26119340 | Active |
Experimental Data Visualization
Trametinib
Statistics Data
Trametinib
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Drosophila melanogaster | 12 | 1 | 2 |
Statistics Data Visualization
Trametinib
