Compound Summary
Compound Information
Plumbagin
Compound Name: | Plumbagin |
Compound CID: | 10205 |
Synonyms: | Plumbagin 481-42-5 Plumbagine 5-Hydroxy-2-methyl-1,4-naphthoquinone Plumbaein More... |
Iupac Name: | 5-hydroxy-2-methylnaphthalene-1,4-dione |
InChI: | InChI=1S/C11H8O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-5,12H,1H3 |
InChIKey: | VCMMXZQDRFWYSE-UHFFFAOYSA-N |
Canonical Smiles: | CC1=CC(=O)C2=C(C1=O)C=CC=C2O |
Isomeric Smiles: | CC1=CC(=O)C2=C(C1=O)C=CC=C2O |
Molecular Weight: | 188.18 |
Molecular Formula: | C11H8O3 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
Plumbagin
Molecular Weight: | 188.18 |
Molecular Formula: | C11H8O3 |
Hydrogen Bond Donor Count: | 1 |
Hydrogen Bond Acceptor Count: | 3 |
Rotatable Bond Count: | 0 |
Heavy Atom Count: | 14 |
Complexity: | 317 |
Synonyms
Plumbagin
| Plumbagin | Plumbagin |
|---|---|
Plumbagin |
481-42-5 |
Plumbagine |
5-Hydroxy-2-methyl-1,4-naphthoquinone |
Plumbaein |
2-Methyljuglone |
5-hydroxy-2-methylnaphthalene-1,4-dione |
Plumbagone |
1,4-Naphthalenedione, 5-hydroxy-2-methyl- |
5-Hydroxy-2-methyl-1,4naphthoquinone |
5-Hydroxy-2-methyl-1,4-naphthalenedione |
2-Methyl-5-hydroxy-1,4-naphthoquinone |
UNII-YAS4TBQ4OQ |
NSC 236613 |
NSC 688284 |
YAS4TBQ4OQ |
5-hydroxy-2-methyl-1,4-dihydronaphthalene-1,4-dione |
CHEBI:8273 |
CHEMBL295316 |
1,4-NAPHTHOQUINONE, 5-HYDROXY-2-METHYL- |
MFCD00001682 |
NSC236613 |
NSC688284 |
NSC-236613 |
NSC-688284 |
ST069355 |
5-Hydroxy-2-methyl-naphthalene-1,4-dione |
plumbapin |
CCRIS 6671 |
SR-05000002263 |
EINECS 207-569-6 |
BRN 1870475 |
Ophioxylin |
Pumbagin |
AI3-38055 |
RTK1 |
1, 5-hydroxy-2-methyl- |
SCHEMBL34186 |
BSPBio_002546 |
4-08-00-02376 (Beilstein Handbook Reference) |
Plumbagin from Plumbago indica |
SPECTRUM1505129 |
GTPL7003 |
PCUR-101 |
DTXSID8075413 |
ACon1_001611 |
ZINC58187 |
HMS3870L13 |
WLN: L66 BV EVJ C1 GQ |
HY-N1497 |
BDBM50012070 |
s4777 |
SBB012388 |
STL564479 |
AKOS015969699 |
CCG-208032 |
CCG-208410 |
MCULE-9327502882 |
NCGC00094567-01 |
NCGC00094567-02 |
NCGC00094567-03 |
NCGC00094567-04 |
NCGC00094567-05 |
NCGC00094567-06 |
BP-25404 |
NCI60_001904 |
PS-11338 |
R242 |
DB-051524 |
CS-0017042 |
FT-0602795 |
P1139 |
5- HYDROXY,2-METHYL-1,4-NAPHTOQUINONE |
A827479 |
1,4-Naphthalenedione, 5-hydroxy-2-methyl- (9CI) |
A1-00788 |
Q2550553 |
SR-05000002263-2 |
SR-05000002263-3 |
W-202844 |
BRD-K36137799-001-02-4 |
BRD-K36137799-001-03-2 |
Experimental Data
Plumbagin
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 200 | umol/L | 20.5 | 3.3 | -0.84 | S | N2 | 21765926 | Inactive | ||||
| Caenorhabditis elegans | 1 | umol/L | 24.2 | 24.5 | 0.01 | 31.2 | 32.3 | 0.04 | NS | N2 | 21765926 | Inactive | |
| Caenorhabditis elegans | 250 | umol/L | 20.5 | 2.8 | -0.86 | S | N2 | 21765926 | Inactive | ||||
| Caenorhabditis elegans | 100 | umol/L | 20.5 | 17.2 | -0.16 | 28 | 23.9 | -0.15 | S | N2 | 21765926 | Inactive | |
| Caenorhabditis elegans | 500 | umol/L | 21.5 | 3.9 | -0.82 | S | N2 | 21765926 | Inactive | ||||
| Caenorhabditis elegans | 2.5 | umol/L | 24.2 | 24.8 | 0.02 | 31.2 | 32.8 | 0.05 | NS | N2 | 21765926 | Inactive | |
| Caenorhabditis elegans | 400 | umol/L | 20.5 | 2 | -0.9 | Unclear | N2 | 21765926 | Inactive | ||||
| Caenorhabditis elegans | 7.5 | umol/L | 24.2 | 24.2 | 0 | 31.2 | 31.3 | 0 | NS | N2 | 21765926 | Inactive | |
| Caenorhabditis elegans | 25 | umol/L | 20.7 | 22.9 | 0.11 | 27.8 | 29.5 | 0.06 | S | N2 | 21765926 | Active | |
| Caenorhabditis elegans | 250 | umol/L | 23.2 | 2.1 | -0.91 | S | N2 | 21765926 | Inactive | ||||
| Caenorhabditis elegans | 100 | umol/L | 22.3 | 19.9 | -0.11 | 26.5 | 23.2 | -0.12 | S | N2 | 21765926 | Inactive | |
| Caenorhabditis elegans | 300 | umol/L | 20.5 | 2.8 | -0.86 | S | N2 | 21765926 | Inactive | ||||
| Caenorhabditis elegans | 50 | umol/L | 20.7 | 23.1 | 0.12 | 27.8 | 31 | 0.12 | S | N2 | 21765926 | Active | |
| Caenorhabditis elegans | 10 | umol/L | 20.7 | 22 | 0.06 | 27.8 | 28.6 | 0.03 | S | N2 | 21765926 | Active | |
| Caenorhabditis elegans | 50 | umol/L | 23.2 | 26 | 0.12 | 29.7 | 31.3 | 0.05 | S | N2 | 21765926 | Active | |
| Caenorhabditis elegans | 150 | umol/L | 20.5 | 15.8 | -0.23 | S | N2 | 21765926 | Inactive | ||||
| Caenorhabditis elegans | 100 | umol/L | 20.7 | 20.8 | 0 | 27.8 | 28.4 | 0.02 | NS | N2 | 21765926 | Inactive | |
| Caenorhabditis elegans | 500 | umol/L | 23.2 | 2 | -0.91 | S | N2 | 21765926 | Inactive | ||||
| Caenorhabditis elegans | 25 | umol/L | 24.2 | 26.9 | 0.11 | 31.2 | 35.3 | 0.13 | S | N2 | 21765926 | Active | |
| Caenorhabditis elegans | 25 | umol/L | 23.2 | 26.5 | 0.14 | 29.7 | 31.1 | 0.05 | S | N2 | 21765926 | Active | |
| Caenorhabditis elegans | 5 | umol/L | 24.2 | 24.8 | 0.02 | 31.2 | 32.1 | 0.03 | NS | N2 | 21765926 | Inactive | |
| Caenorhabditis elegans | 25 | umol/L | 20.5 | 22.5 | 0.1 | 28 | 28.6 | 0.02 | S | N2 | 21765926 | Active | |
| Caenorhabditis elegans | 50 | umol/L | 20.5 | 19.9 | -0.03 | 28 | 26.4 | -0.06 | S | N2 | 21765926 | Inactive | |
| Caenorhabditis elegans | 10 | umol/L | 20.5 | 22.3 | 0.09 | 28 | 28.6 | 0.02 | NS | N2 | 21765926 | Inactive |
Experimental Data Visualization
Plumbagin
Statistics Data
Plumbagin
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 0.14 | 0.13 | 1 | 24 |
Statistics Data Visualization
Plumbagin
